Howard becomes nervous after NASA asks him to throw out the first pitch at a Los Angeles Angels game. Meanwhile, Leonard and Penny try to prove Sheldon wrong when he says that he and Amy have a 'superior' relationship.
Sheldon and Raj test whether they could survive a dark-matter research expedition in a salt mine by simulating the conditions in a steam tunnel. Meanwhile, Leonard and Penny seek advice from Howard and Bernadette when they argue about money.
Howard receives some shocking news as everyone prepares for the re-opening of the comic book store. Meanwhile, Penny tries to teach Sheldon how to "let it go," but can't follow her own advice when she learns something infuriating about Amy.
Sheldon and Penny agree to participate in an unusual experiment. Leonard, Amy, Raj and Emily spend the evening trying to escape a room with a "zombie". Howard and Bernadette run into trouble at the airport after returning from Mrs. Wolowitz's funeral.
A trip to the pet store ends in a fight after Amy learns Sheldon has applied for a one-way mission to colonize Mars. Meanwhile, Leonard surprises Penny with a very "adult" purchase, and Raj gets into trouble when he snoops around Emily's apartment.
When Leonard and Sheldon are invited to speak at UC Berkeley, they take a detour to try and meet one of their idols. Meanwhile, while cleaning out Mrs. Wolowitz's house, a ping pong battle ensues when Howard and Bernadette argue over the fate of his TARDIS.
When Sheldon and Amy build a blanket fort, they come to major crossroads in their relationship. Meanwhile, Howard meets the half-brother he never knew he had, and Penny is invited to appear on Wil Wheaton's podcast.
Howard questions his engineering abilities when he and Sheldon can't get a toy drone to fly. A cancelled flight nearly prevents Leonard from giving the commencement address at his former high school. Raj pits his parents against each other when his father cuts him off financially.
As Sheldon presses Leonard and Penny to set a wedding date, he encounters major changes in his relationship with Amy. Meanwhile, Raj wonders if he should break up with Emily, and Howard and Bernadette struggle to ask Stuart to move out.