Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Caltech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Caltech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by
Smart Is The New Sexy.
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Did You Know?
Both Raj's and Bernadette and Howard's apartment are filmed on the same set and are just completely redecorated to change scene, this is why it is rare to see both apartments in one episode. See more
A line of the opening song states 'Neanderthals developed tools'. Homo habilis actually developed tools long before the Neanderthals. See more
[repeated line when someone accuses Sheldon of being crazy
I'm not crazy. My mother had me tested!
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
History of Everything (Instrumental)
Composed by Barenaked Ladies
Performed by Barenaked Ladies
Played during the end credits See more