Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Caltech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Caltech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by
Smart Is The New Sexy.
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Did You Know?
audition for the role of Dr. Sheldon Cooper was so good that creator Chuck Lorre immediately asked Parsons to come in for a second one, because Lorre wanted to be 100% sure Parsons was as brilliant as he seemed. After the 2nd audition went perfectly, Lorre cast Parsons on the spot. See more
In one of the episodes when Sheldon moves in with Raj, Raj is watching an Indian movie. The actress of that movie is referred to as 'Aishvarya Rai', but it's actually 'Amisha Patel'. See more
[repeated line when someone calls Sheldon crazy
I'm not crazy! My mother had me tested.
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more