Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Caltech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Caltech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with popular women. When Penny, a pretty woman and an aspiring actress originally from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend. Written by
When beauty meets the brains.
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Did You Know?
The theme song uses the line "Autotrophs began to drool." This is a science joke. The word "autotroph" means "self-nourishing" and refers to life-forms (plants and algae) that create their own food internally and don't need to eat. See more
The opening titles are based on a time line of human history. A picture of Abraham Lincoln is followed by a picture of George Washington. See more
[repeated line when someone accuses Sheldon of being crazy
I'm not crazy. My mother had me tested!
One of the final cards to appear in the credit sequence is the vanity card for Chuck Lorre Productions. In keeping with his practice on "Dharma and Greg" and "Two and a Half Men", there is a different message on the card each week, written by Chuck Lorre himself. See more
History of Everything (Instrumental)
Composed by Barenaked Ladies
Performed by Barenaked Ladies
Played during the end credits See more