Clarissa says she's always wanted to live in New York. In reality, Melissa Joan Hart did live in New York when she wasn't in Orlando filming this show.
Clarissa's final line, "Maybe this isn't goodbye. Maybe this is a new beginning. You never know", was a reference to the pilot they intended to make for a spinoff series on CBS, which would follow Clarissa to New York. The pilot was filmed, but ultimately wasn't picked up.
This is the series finale.