The phone conversation at midnight between Frost and Nixon never actually happened. Screenwriter Peter Morgan got the inspiration from well-known phone calls at midnight that Nixon did to some government members during Watergate.
Frank Langella admits that he usually enjoys playing cards and joking around on movie sets, but felt it would compromise his character if he didn't remain presidential on this set. While working on this movie other cast and crew referred to him as "Mr. President." Langella suggests almost none of the crew ever met Frank Langella.
In an article called 'Stopping the Rot' in The Sydney Morning Herald (Australia) on May 3, 2008, Ian Munro quoted James Reston Jr., Frost's Watergate adviser: 'I was in army intelligence ... and the Mutt and Jeff, good cop-bad cop thing is usually two people, but Frost, he did both roles.'
When Frost is on the phone talking about syndicating the interview we can see that the television behind him is showing the famous "Crying Indian" Public Service Announcement that aired all through the 1970s.
Oliver Platt previously played Yankees Owner George Steinbrenner in the ESPN mini series The Bronx Is Burning. In 1974, Steinbrenner was convicted and suspended from baseball due to illegal contributions made to Nixon's 1972 Re-Election Campaign.
The Broadway production of "Frost/Nixon" by Peter Morgan opened at the Bernard B. Jacobs Theater in New York on April 22, 2007, ran for 137 performances and was nominated for the 2007 Tony Award for Best Play.
The actual interviews were conducted at a home in Dana Point, California. This was because Nixon's house in San Clemente was too near a Coast Guard facility that caused interference to the TV equipment.