Consistent with House's parallels with Sherlock Holmes, when he challenges his team to solve the puzzle of the diagnosis, he writes it on a piece of paper, puts it in an envelope and on the envelope writes "The game is a itchy foot." This is a play on words of Holmes' popular phrase, "The game is afoot."
The physical therapist berates House's use of his cane on the wrong side. Some patients who use a cane long term will use it on the side that is injured or on the opposite side. It comes down to personal preference and ease of use though therapists will always recommend the uninjured side.
The trivia item below may give away important plot points.
One patient multiple diagnoses- First diagnosis Hepatitis A, Second diagnosis Osteomyelitis, Third diagnosis Syphilis, Fourth diagnosis Eikenella, Fifth diagnosis Botulism. The cause of the patient contracting all of these illnesses at once is Chronic Granulomatosis Disease, which shut down his immune system.