In April 2008, Rocky the Grizzly Bear, who wrestles Will Ferrell's character in this movie, killed Stephan Miller, one of his trainers and a cousin of a stuntman doubling for Ferrell, by biting him on the neck.
In the film, Jackie Moon says that he had never vomited before, not even as a baby. In reality, Will Ferrell suffered from pyloric stenosis, a condition that causes frequent vomiting, as a baby. A scar on his upper right abdomen, from the surgery he had to treat this condition, appears in this and many other films.
The melody to Jackie Moon's theme song "Love Me Sexy" largely came about from Will Ferrell's first table read of the script. Director Kent Alterman sent leading record producer Nile Rodgers a recording of the improv that Ferrell did on that day, and Rodgers built up the song from around that.
During the Tropics game with the San Antonio Spurs, a banner can be seen on the sideline that reads "WOAI". These are the call letters for an actual San Antonio radio sation (AM 1200) that continues to carry San Antonio Spurs games to this day.
The second Will Ferrell film in which his character is caught in a 'fight' situation with a bear, previously Anchorman in which Ron Burgandy aims to fend off bears in order to save Veronica Corningstone (Played by Christina Applegate)
Lou Redwood threatens Cornelius Blanks with a Smith & Wesson Model 19 revolver, with a 4-inch barrel. It was commonly issued to police officers in the 1970s, and is still carried by some. Like most .357 revolvers, it can fire .357 or .38 and .38+P rounds.