The filmmakers chose to show a postcard version of Paris in the movie, inspired by such films as Madeline (1998), The Red Balloon (1956), Jacques Tati's films and Ratatouille (2007). As such the film takes place in modern, but slightly anachronistic Paris.
Jean Reno chose to reprise his role due to the good experience he had working on the previous film, his friendship with Steve Martin, his joy at working with Alfred Molina again after The Da Vinci Code (2006) and his pleasure at working between Paris and Boston.
Despite a rather extensive publicity campaign, a predominantly French setting, its hero being a French detective and the presence of one of France's most popular actors (Jean Reno) in the cast, the film was a huge commercial failure in France, lasting merely one week in most major multiplexes.
Aishwarya Rai Bachchan quickly accepted the part of Sonia Solandres as she grew up watching the original films and Steve Martin's previous films and she knew families would enjoy viewing it and have a good laugh, especially her husband Abhishek Bachchan's niece and nephew.
British singer Emma Bunton had won the lead female role of The Pink Panther 2, and was supposed to be filming in Autumn 2007 for release in 2008. She was tapped to replace Beyoncé Knowles as the female lead in this sequel, named Milly Baxter. Unfortunately, the ex-Spice Girls member was forced to drop out because of her pregnancy and her tour commitments. Subsequently, Bunton's character was deleted.
Harald Zwart: [Fredrikstad] Zwart puts objects from his hometown in all of his movies. In this movie you can see a flag for the Norwegian soccer team Fredrikstad FK in the rucksack of Ponton's sons. It is visible when the sons and Inspector Clouseau are comparing their medals.
SERIES TRADEMARK: When Clouseau is shot by Sonia, Dreyfuss says that he wished he was the one who shot him. In the previous movies, Dreyfuss (as played by Herbert Lom) was obsessed with killing Clouseau.