When we see Julia Roberts and Bradley Cooper for the first time, the captain says "...three days of rain". The two starred together on Broadway in a play called "Three Days of Rain" in 2006. It received terrible reviews and ran for just 70 performances.
When Edgar is at the cemetery before the movie starts, on the movie screen is the title of the movie, Hot Spell (1958), and pictures the two main characters. He mentions that the woman on the screen is his trifecta. When asked if he means literally the actress on the screen. He says "Yes, literally." The actress on the screen is Shirley MacLaine, who plays his wife in the movie.
Ashton Kutcher and Topher Grace starred on That '70s Show (1998) for the first seven seasons, and left either before or during the eighth season. They returned to the finale, and returned in this movie four years after the series ended.
Since Captain Kate Hazeltine (Julia Roberts) wears the patch of the 101st Airborne on both shoulders, the left shoulder signifies that she is presently serving with that unit, and the right shoulder signifies she served with that unit in combat.
In the film, Julia Fitzpatrick rants to Dr. Harrison Copeland about being fourteen and "...[having] cystic acne and braces and [playing] the saxophone in the marching band..." Jennifer Garner, who plays Julia Fitzpatrick, played the saxophone in a marching band when she was in school.
DITRADE(Garry Marshall): As he often does in his movies, Garry Marshall cast many of his family members in small roles in this movie: Reed's coworker Nikki is played by Marshall's daughter Kathleen Marshall; Mr. Schwabbe is played by his son Scott Marshall; grandchildren Sam Marshall and Lily Marshall-Fricker play "Soccer Son" and Lily, respectively; wife Barbara Marshall plays the nurse who tells Julia where Harrison is eating dinner; and niece Tracy Reiner plays a French photographer. Marshall also shot a scene with his sister, director Penny Marshall, in it, but it didn't make the final cut.
Kathy Bates originally played Frankie in the play "Frankie and Johnny at the Clair de Lune," which was turned into the film Frankie and Johnny (1991), directed by Garry Marshall. This was filmed before Misery (1990) became a hit and turned Bates into a well-known actress, so she was not cast in the film version. In this film, she finally works with Marshall.
James F. McCann:
The founder and CEO of 1-800-FLOWERS.COM appears as a customer in a deleted flower shop scene when Reed tries to soothe the tense customers by asking them to name their favorite love song.