Stepping out of the back of the eighteen-wheeler he was riding in, Michael Westen is greeted with an exploding plane, dead bodies, and one hog-tied, live "client", Jimmy. The phone rings, and a female voice, calling herself "Carla", lets Michael know that if he gets this man back to Miami, and help him play ball, she will finally let him know who burned him. After agreeing to help his new client, Jimmy, steal data from the fortress at Security Associates, and get the man's family back, who are now being held hostage, Michael enlists the help of his friends Fiona and ...
While Michael's new handler asks him to locate a Tunisian counterfeiter, Sam asks him to help a woman who says she is being stalked by a drug dealer, and his mother asks him to join her in seeing a therapist.
Michael tries to help a man who lost the money he owes to loan sharks to a conman, and blackmails a Pakistani spy in order to get information about his new operative. Meanwhile, Michael's mother asks Fi about their breakup.
Michael's brother shows up to ask him to help a Russian woman whose sister is being held by Russian mobsters, and Sam tries to work a local agriculture source to find out more information about Michael's handler.
Michael poses as a safe cracker to help out a reformed ex-con who is unwittingly part of a heist, and tries to sneak into the heavily-guarded office of his handler. Meanwhile, Sam gets an unexpected proposition from his girlfriend.
Michael and Sam are busy running counter-surveillance on Carla and the sniper. However, the job is interrupted when Fiona's new boyfriend asks Michael to help a friend involved in a kidnapping conspiracy plot.
Michael has questions for Carla, and he wants to know who tried to blow him up. But first he goes after a group of medical scam artists who stole the life savings from a man trying to take care of his sick child.
Michael captures the rogue agent responsible for trying to bomb him, but he decides to form an alliance with him and together go after Carla and her boss. But that decision also puts Michael's mother in jeopardy.