Early in the movie as the inspector checks the body, everything, as noted elsewhere, signals temperatures below freezing. Yet you hear the sounds of buzzing flies, which would not occur in that kind of cold.
After the train collision towards the end of the film, Jesse is carried off in a stretcher. An oxygen mask is placed over her face. The hand of a medic is seen squeezing the airbag. In a real medical situation, there is no need to squeeze the bag for someone who is already breathing. In fact, it could be dangerous.
When Carlos places the camera around Jessie's neck in the church scene, it can be seen that the green neckstrap has prominent bold CANON logos on it. A split second later, she is wearing a brownish neckstrap with no logos or writing on it.
At one point in the movie Jessie is moving along the corridor of the train. A man with a freshly lit cigarette hanging from his lips is standing in the aisle as she approaches, as she passes him the camera pans back to the same guy who now has an almost finished cigarette in his mouth.
The English-language subtitles refer to one of the station stops as "Ulyanovsk." Ulyanovsk is a major city southeast of Moscow, not at all on the route of the Trans-Siberian railway. The correct name is "Ilanovskaya," seen on the hotel sign and on the travel brochure Carlos hands to Jessie. The error appears only in the subtitles, as the actors pronounce the name correctly.
Roy and Jessie set out from Beijing and immediately deal with Russian staff on the train. In fact, the train is manned by Chinese staff with a Chinese restaurant carriage whilst the train is still in China.
When Jessie first tries to get rid of the matreshkas (set of nesting dolls) made of drugs, she goes to the carriage platform and opens the door by rotating the red lever covered by frost. It's actually an emergency hand brake.
When Jessie delivers the fourth plank blow to Carlos (one to the arm, one to the back, one to the side of the face, one to the forehead), Carlos drops to his knees in front of her. Then she delivers two major blows to the top of his head, killing him. He falls face down in front of her. Brief cut to a crow on a tree branch. When the camera returns to the scene, Carlos' body is lying FACE UP in the snow, while Jessie ponders what to do next.
Grinko wears his wedding ring on left hand. While Russians (as well as many other nations of the former Soviet Union) actually wear wedding rings on right hand, they will wear wedding rings on their left hands when they are divorced or widowed.
The large map that Jesse studies in the movie says "All Abroad" in very large letters, instead of "All Aboard". This is a reference to English language signs in China that sometimes have amusing mistakes in them.
When Detective Grinko is scrolling through photos on the camera, the images are seen going BACK through time (this is logical - the photo view mode starts with the most recent photo and you scroll backwards to go back). We see the photos of the paintings in the church, then the eagle etc. However, he is pressing the RIGHT button - this would cause the photos to scroll forwards in time (to the right). He should be pressing the LEFT button in order for the camera to scroll backwards as it is shown.
The shots Jessie takes near the old church require a large telephoto lens (especially the one of the soaring eagle). Her camera, however, is mounted with a very short focal length lens than is incapable of taking said pictures.
About five to six minutes into the movie, immediately after the scene where Jesse is looking at the large route map, the is a brief shot of train cars moving past the camera to the left. The serial numbers on the cars are flipped meaning that this portion of the film must have been flipped during printing.
When Jessie is taking photos with her Canon EOS Digital SLR, the view through the camera is shown. This is not through a Canon, which shows focus points, as opposed to the central focus circle shown on the film.
The goof items below may give away important plot points.
When the main characters are in the car, driving on the streets of Moscow, you can see a video ad of Double Coffee (with a lake and a house in the background). It's a Latvian coffee house company operating in the Baltic States and Ukraine, and not in Russia.
At the end of the movie, the main couple drives a train. A locomotive with three cars. Jessie closes all the doors of the cars and then goes back to Roy, who is operating the locomotive. But there is no way to get from the cars to the locomotive.
When Jessie runs out of the church, just before she kills Carlos, there's no camera around her neck, despite the central role of the camera in the plot. However, before Jessie leaves the church she puts the camera in her backpack.