Marlon Wayans, who originally created the "Scary Movie" franchise alongside his brothers Keenen Ivory and Shawn back in 2000, told in an interview that the studio asked the Wayans Brothers to return for "Scary Movie 5", but the brothers declined. Marlon Wayans later released his own horror movie spoof "A Haunted House" (2013) which performed so well at the box office that it spawned its own franchise, with "A Haunted House 2" to be released in 2014.
The spell 'Gort Klaatu Barada Nikto' was originally heard in the 1951 science fiction movie "The Day the Earth Stood Still" as a phrase with which to awaken Gort, the mechanical guardian, and ordering him to protect Klaatu, the alien visitor played by Michael Renny. The phrase was also used in the movie's 2008 remake starring Keanu Reeves and Jennifer Connelly.
David Zucker told in an interview that the movie's release actually had a 3 year wait because the studio tried to convince him to return to direct. Finally, the studio and Zucker agreed that Zucker returns, but as a writer. Then the studio hired Malcolm D. Lee to direct after Lee helmed "Soul Men" (2008) for the same studio. Before Zucker was added to write, the initial script was delivered by writers Stephen Leff, John Aboud and Michael Colton. Zucker rewrote it first together with Lee and later again with his long-time writing partner Pat Proft.
Since Here Comes Honey Boo Boo (2012) isn't very known in Germany, the reference to the show was replaced by I'm a Celebrity, Get Me Out of Here! (2003) in the German dubbed version, which is a hit reality series on German TV - similar changes were also made in other countries, such as Brazil. The dubbing actor who voices Dom Kolb in the German version is actually the same who usually dubs Leonardo DiCaprio.
Filming begun on Tuesday, September 4, 2012 and wrapped on Thursday, October 25, 2012. Additional footage recordings and re-shoots occurred between January and February, 2013 with ADR sessions taking part in March and April.
David Zucker directed the additional/re-shoots from January to February 2013. Main actress Ashley Tisdale told in several interviews that the material from the re-shoots (and ADR sessions) make about 60% of the final theatrical cut. Director Malcolm D. Lee didn't have anything to do with the editings since he was already engaged in doing "The Best Man Holiday" (2013) by the time they did them. Lee didn't even show up at the "Scary Movie 5" premiere in LA for unknown reasons.
Both David Zucker and the sound mixer, Chris Durfy are avid Green Bay Packers fans and Wisconsin natives. They both have a cameo in the Black Swan spoof near the end of the movie dressed as Packer fans for the Lambeau Leap.
"The Evil Dead" is spoofed although it was released only one week before "Scary Movie 5". The "Scary" producers approached the "Evil Dead" script and basically spoofed the trailer. The "Fifty Shades of Grey" movie isn't even in production yet, but is already spoofed in this film.