Director and writer David Zucker said in an interview that the movie's release actually had a three-year wait because the studio tried to convince him to return to direct. Finally, the studio and Zucker agreed that Zucker returns, but as a writer. Then the studio hired Malcolm D. Lee to direct after Lee helmed Soul Men (2008) for the same studio. Before Zucker was added to write, the initial script was delivered by writers Stephen Leff, John Aboud and Michael Colton. Zucker rewrote it first together with Lee and later again with his long-time writing partner Pat Proft.
Marlon Wayans, who originally created the "Scary Movie" franchise alongside his brothers Keenen Ivory Wayans and Shawn Wayans back in 2000, said in an interview that the studio asked the Wayans Brothers to return for Scary Movie 5 (2013), but the brothers declined. Marlon Wayans later released his own horror movie spoof, A Haunted House (2013), which performed so well at the box office that it spawned its own franchise, with A Haunted House 2 (2014) released the following year.
The Evil Dead (2013) remake is spoofed in this movie, although it was released only one week before. The "Scary Movie" producers approached the Evil Dead (2013) script and basically spoofed the trailer. The Fifty Shades of Grey (2015) movie was not even in production yet, but it was already spoofed in this film.
David Zucker directed the additional/re-shoots from January to February 2013. Main actress Ashley Tisdale said in several interviews that the material from the re-shoots (and ADR sessions) made about 60% of the final theatrical cut. Director Malcolm D. Lee did not have anything to do with the editings since he was already engaged in doing The Best Man Holiday (2013) by the time they did them. Lee did not even show up at the Scary Movie 5 (2013) premiere in Los Angeles, for unknown reasons.
Since Here Comes Honey Boo Boo (2012) was not very known in Germany, the reference to the show was replaced by I'm a Celebrity, Get Me Out of Here! (2003), a hit reality series on German TV, in the German-dubbed version. Similar changes were also made in other countries, such as in Brazil. The dubbing actor who voiced Dom Kolb in the German version was actually the same person who usually dubbed Leonardo DiCaprio.
The spell "Gort Klaatu Barada Nikto" was originally heard in the 1951 science fiction movie The Day the Earth Stood Still (1951) as a phrase with which to awaken Gort, the mechanical guardian, and ordering him to protect Klaatu, the alien visitor played by Michael Renny. The phrase was also used in the movie's 2008 remake starring Keanu Reeves and Jennifer Connelly, and a similar phrase is used in Army of Darkness (1992).
Ted appeared on the cover but did not make the film's theatrical final cut. In the Blu-ray extended version, Ted appears in the Jody Black Swan intimate, drug fueled encounter with Kendra, as among the many bedroom attendees in intercourse.
In the scene where Charlie Sheen and Lindsay Lohan are in bed and the cat jumps on the bed, Sheen says, "Get out of here, Emilio!" This is likely to be a reference to Sheen's brother, actor Emilio Estevez.
Both director/writer David Zucker and the sound mixer, Chris Durfy, are avid Green Bay Packers fans and Wisconsin natives. They both have a cameo in the Black Swan (2010) spoof near the end of the movie, dressed as Packer fans for the "Lambeau Leap."
The filming for this movie began on Tuesday, September 4, 2012 and wrapped on Thursday, October 25, 2012. Additional footage recordings and re-shoots occurred between January and February, 2013, with ADR sessions taking part in March and April.
The film was originally slated for a 2008 release, but there were no updates at the time. However, the film was then slated for a 2011 release. During that year, it was announced for an April 20, 2012 release. Two months prior to that date, it was delayed for January 11, 2013. Due to rewrites and production being postponed, the film was pushed for April 19, 2013. However, the release changed to April 12, due to the Evil Dead (2013) remake originally being released during that date (although it changed to April 5th).
David Zucker offered a small role to Donna Harrison before "Scary Movie 5" was in the works. Her scene was shot, however it was cut from the movie and it was not found on the Deleted Scenes section of the DVD.
The saying "Klaatu Barada Nikto" was also used in The Evil Dead (1981) by Ash, to summon up the demon from the Necronomicon Ex Mortis, the Book of the Dead. (Ash also screws up reciting the phrase, thus causing all sorts of problems in Army of Darkness (1992) too). Incidentally, Nikto was also the name of a chatacter that appeared in Jabba the Hutt's palace in Star Wars: Episode VI - Return of the Jedi (1983). The saying originates from The Day The Earth Stood Still and is used to 'calm' Gort down.