Mentioned in the behind the scenes special features, Emma Roberts tripped and fell while shooting the escape from the shelter. As a result, she was run over and trampled by the dogs, but was unhurt. She apparently had paw prints all over her.
Many different types of dogs can be seen in the film: Lenny is a Bullmastiff, Georgia is a Boston Terrier, Cooper is a English Bulldog, Shep is a Border Collie, Romeo is a Chinese Crested Dog, Juliet is a Poodle and Henry is a Beauceron.
Special effects coordinator Michael Lantieri found the making of the ball-throwing machine particularly challenging due to the many settings that had to be calculated and adjusted, such as the ball's weight, the synchronization between the hand's movement and the moment when the ball is thrown, etc...
One of 3 movies in which Emma Roberts has co-starred with a female lead from the TV series Friends. In Hotel for Dogs, she worked with Lisa Kudrow. She later worked with Courteney Cox in Scream 4 and with Jennifer Aniston in We're the Millers.