The victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
Derek lets his emotions run away from him, and Burke and Izzie make a new suggestion to Denny. Meanwhile, the interns treat a family involved in an auto accident, Callie makes Meredith and Izzie uncomfortable, and Addison strikes back at Alex.—Alex