A soldier, wounded in Iraq by shrapnel to his head, suffers a stroke, which leads to paralysis in his leaf arm. Elsewhere, a woman is diagnosed with a so-called joking disease caused by a tumor that makes her lose memory and find most things humorous.
Erica Lund, a young girl, is admitted to Hanso Neuro as she's been experiencing violent seizures. However, she's refusing to have surgery because she has euphoric moments before each episode. Elsewhere, patient Matt Ketchum is being treated for a traumatic head wound that causes him to blurt out his most intimate thoughts.
A young man has a motorcycle accident, and goes into a coma. After a round of tests it is discovered that he is responsive to the sound of his girfriend's voice. Adrianne had a relationship like this when she was young. Hanson has to convince his daughter that it is okay that her mother sells their house.
Hanson decides to do a cutting edge procedure on a man who is suffering from severe clinical depression. He cannot be cured with medication. The technique is to use electrodes to stimulate the part of the brain that causes happiness. This spurs a whole debate between the doctors about how the human brain controls emotion -- or does a soul determine emotion?