House M.D.: Season 2, Episode 16

Safe (4 Apr. 2006)

TV Episode  |  TV-14  |   |  Drama, Mystery
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6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean room bedroom after her boyfriend almost kisses her and discovers something on her arm.


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Episode cast overview:
Barbara Bardach
Lewis Bardach


Melinda Bardach has been kept in a quarantine bubble at home by her over-protective parents since her heart-transplant months ago. After a kiss from her adolescent boyfriend Dan, she is brought in with a sudden series of symptoms varying from anaphylaxis, heart failure to paralysis. According possible syndromes must be eliminated, including her penicillin allergy as House cleverly guesses that Dan felt guilty he might contaminate her so took pills. However he wasn't sure which exactly, and that residue can be passed on through otherwise healthy semen, but again another theory is needed. Meanwhile House now is determined to keep poor divorcing Wilson in his home, mainly to torture the tidy gentleman. Written by KGF Vissers

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Drama | Mystery


TV-14 | See all certifications »

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Release Date:

4 April 2006 (USA)  »

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Aspect Ratio:

1.78 : 1
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Did You Know?


The film that House and Wilson are watching at the end of this episode is Vertigo (1958). See more »


The tick House pulls out at the end has six legs (which is excellently visible in a close-up on his gloved hand) - this would indicate it is an insect. But ticks are arachnids, not insects; and, as all other arachnids (such as spiders or scorpions), they have eight legs, while the insects have six. See more »


Dr. Eric Foreman: [to Cameron] So I hear you don't want teenagers having sex. Teen suicide rate isn't high enough for you already?
See more »


Features Vertigo (1958) See more »


Pain In My Heart
Performed by Otis Redding
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User Reviews

Inner demon
4 September 2006 | by (Connecticut) – See all my reviews

Michelle Trachtenberg acts her little heart out in an episode that depends heavily on her star-turning performance as an immuno-suppressed heart transplant patient who suddenly develops unexplained symptoms. Scenes with her as she grows increasingly sick are incredibly harrowing, partly due to the sickly makeup she sports but mostly due to Michelle's utterly convincing performance. The solution is about as risqué and groundbreaking as I have seen on a TV show. It's also hysterical. Wilson saves House's hide in this one by buying him some precious time. Good old Watson. Oops, I mean Wilson. Michell's mom is played by a TV actress not seen in some time, Mel Harris of "30 Something" infamy. Whatever happened to her? Dad is played by that Last Starfighter, Lance Guest. Whatever happened to him? Only the most stalwart among you are likely to recognize this one-time, curly-haired teen heartthrob now turned bearded, balding, middle-aged dad.

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