The Simpsons: Season 4, Episode 18
So It's Come to This: A Simpsons Clip Show (1 Apr. 1993)
Homer plays a series of (childish) practical jokes on Bart. To get even, Bart uses a paint mixer at a local hardware store to shake up a can of Homer's beer. Homer opens the can, resulting in a huge explosion that seriously injures the Simpsons patriarch.