Dan Castellaneta who voices the alcoholic Barney is actually teetotaler in real life.
The character's new addiction to coffee was suggested by writer/producer David Mirkin, who had friends that had stopped drinking alcohol and became addicted to coffee.
"She-Hulk vs. Leon Spinks" is reminiscent of the 1970's comic "Muhammad Ali vs. Superman".
During Operation Desert Storm, the Iraqis dropped propaganda leaflets stating that American soldiers' wives were having affairs with Bart Simpson and Burt Reynolds.
As the mail lady drops Moe's mail through the mail slot, we see that his address is 57 Walnut Street.