Around the same time as this episode was produced, the series' regular cast took Jennifer Lien out to dinner and she had a poignant discussion with Janeway actress Kate Mulgrew on the same night. Mulgrew later remembered, "I drove her home and said, 'This could be serendipity, Jen. You're so unusual and so deep and fine. I believe it's the beginning of a stellar career.'" Unfortunately Mulgrew was VERY wrong. Lien only had one more minor acting roll and one (possibly two) voice rolls and had several run-ins with the law resulting in multiple arrests.
This was the last regular episode of Star Trek: Voyager that starred Jennifer Lien as Kes. Bryan Fuller noted that the reason for this episode's change in production order was "because of Jennifer Lien's schedule."
This is the second episode in which the main characters from all seasons (including both Kes and Seven of Nine) appear, the first being the previous episode, "Scorpion, Part II", and the third and final episode being "Fury", the only episode after this one to feature the character of Kes.
Like TNG: "Family", this episode deals with the ramifications of a Borg-related two-parter whose second part features a Human character (a regular of the series) being separated from the Borg. (The TNG two-parter is "The Best of Both Worlds" and "The Best of Both Worlds, Part II", in which Picard is assimilated and then separated from the Collective, whereas the VOY two-parter is "Scorpion" and "Scorpion, Part II", wherein Seven of Nine is separated from the Collective).
The trivia items below may give away important plot points.
Kes leaves Voyager in this one. The staff felt that Kes' character arc had been taken as far as it would go, so actress Jennifer Lien was released from her contract and asked to leave the show. After this, Kes makes a guest appearance in the season six episode Star Trek: Voyager: Fury (2000).