The first-draft script of this show was to be set in 2017, with futuristic costumes and gadgetry and old Dr. Auschlander still going via bionic implants all over his body. NBC balked at the cost of filming that show, and this script was made up just before the writers' strike of 1988 (it was filmed after the writers went on the picket lines in mid-March, with the last scene completed being a big kiss between Dr. Erlich and Nurse Papandreou).
Full of inside jokes, including a doctor named Brandon Falsey, a reference to Brand and Falsey, the creators of the show. There was a chase of a "one armed man" a reference to the Fugitive. During the chase, someone yells, "Move the gurney, Hal," a reference to Hal Gurnee, Dave Letterman's director. The founder of NBC "General" David Sarnoff (died in 1971) makes an appearance a character who is having trouble with his eyesight because he watches too much television.
The trivia item below may give away important plot points.
In the infamous final scene, Auschlander asks Westphall (who is dressed as a construction worker): "How was your day up on the building?" and Westphall replies: "Well, we finally topped off the 22nd storey." This is a sly nod to the fact that the episode is number #6.22 - in other words, the season's 22nd story.