This is the first appearance of Dr. Ashley Kafka, a psychiatrist for the criminally insane at Ravencroft Institute for the Criminally Insane, outside of the comics. She was created only a few years prior in 1991 first appearing in "The Spectacular Spider-Man" (Vol. 1) #178.
The Kletus Kassidy scenes are inspired by "The Amazing Spider-Man (Vol. 1) #359. The Ravencroft scenes with Eddie Brock and Kletus Cassidy are inspired by the quick panels from "The Amazing Spider-Man" (Vol. 1) #344 and #345. The main difference here is that Eddie Brock and Kletus Kassidy aren't cellmates kept in the same cell.
This episode crosses over with Iron Man (1994). War Machine/James Rhodes makes an appearance and is voiced by James Avery and Tony Stark appears voiced by Robert Hays. This means that this episode takes place during or before the first 8 episodes of Iron Man (1994).
The Newscaster from The Alien Costume, Part One (1995) appears in this episode and is again voiced by John Beard. In real life, Beard is an actual newscaster for KTTV a FOX owned and operated TV station in Los Angeles.