Dr. Mariah Crawford is an original character to this series, but she is loosely inspired by Calypso, a Haitian voodoo priestess who was associated with Kraven the Hunter. In fact, Kraven always refers to Dr. Crawford as his "Calypso" in this series.
This episode is loosely based on "The Amazing Spider-Man" (Vol. 1) #15. Instead of the Chameleon asking Kraven to hunt and kill Spider-Man, the two come into conflict with each other of due to Spider-Man intervening in the affairs between Kraven and Dr. Mariah Crawford.
This is the 6th episode of the series. However, it was the seventh episode to air on FOX.
This episode was adapted to "Spider-Man Adventures" #6, which is a comic book series based on this animated series.