Whenever Towellie gets high, the Popeye theme tune plays, just like when Popeye ate spinach.
Cartman says "But I don't think it's for usin'. I think it's just for lookin' through."
Towlie says, "Don't forget to bring a towel," a reference to the sound advice of The Guide.
The line "Perhaps they're telepathically linked with the towell like E.T."
Tynacorp is based on Cyberdyne from this movie. Also, the climax takes place above a huge pool of molten metal.
Cartman quotes lines from Sling Blade after finding Stan's mom's bloody tampon.
The video game announcer says "Multi Kill", just like in Unreal Tournament.
The boys encounter several malformed towels, being the result of bad cloning experiments. One also says "Kill me", just like the 7th Ripley clone in Alien: Resurrection.