The group of people running out of the zoo, before Homer, Bart, and Lisa, are caricatures of Mike Scully, his wife, and his children.
Features the Canyonero van, and snippets of its theme song, from The Last Temptation of Krusty (1998).
The idea behind the episode came from a study performed that showed women had more cases of road rage than men.
The names of the other car salesmen on the board in the car garage are friends of Mike Scully from high school.
The episode's title is a reference to "Screaming Yellow Zonkers", a snack food introduced in the US in the 1960s. It consisted of popcorn with a yellow sugary glaze and was packed in a black box.