Barney sings "I Am the Very Model of a Modern Major-General."
When experiencing extreme G-forces Homer's head turns into that of Popeye and his voice changes to that too.
When the Simpson family first reaches Cape Canaveral, they are driving in a car similar to the car from the television series, accompanied by 'The Beverley Hillbillies' music
One of the astronauts is named Race Bannon, a character from Jonny Quest.
Homer says there'll be no problem as long as he isn't sent to "That planet of the apes", then he stops to think and realises that it was Earth and re-enacts the end scene of the film.
The phrase spoken by Kent Brockman: "I, for one, welcome our new insect overlords" is a reference to this movie.
Scar Trek: The Next Laceration is the name of the Itchy & Scratchy toon, which lampoons this show's name.
Episode name "Deep Space Homer" references the name of this series.
Homer shows Frank a photo of him as an astronaut and mentions going to space
The carbon rod from this episode is a collectable card. The episode name and quotes from the episode are written on it.
"Inanimate Carbon Rod" is an available "salvage" item in the game.
Peter Baynam makes a joke where he starts to talk about a well-known scene from an episode of the simpsons, only to realise he's talking about the wrong show, he then says "Oh wait, that's The Simpsons".
Homer eat chips in zero gravity
Ken writes "I for one welcome our new computer overlords" after his Final Jeopardy response, referring to Kent Brockman's statement about insects in the episode
A series of clips play to demonstrate Homer's stupidity using a clip from this episode.
Homer loves the words "default"
The shot of the family riding in the car with Marge in a rocking chair is a spoof of this show's opening.
The scene of Homer and Barney pitched against each other spoofs the gladiator fights this episode, including the outfits, Green haired Shahna looking on and the music Amok Time.
Many scenes including part of the itchy & scratchy episode, the scene of Homer floating in space eating chips to classical music and the end scene where Bart throws a marker pen into the sky for it to cut to a Fox satellite in space.
Itchy bursts out of Scratchy's stomach, spoofing the alien bursting out of a man's stomach scene in this movie.
Many scenes like the NASA's tests with Homer and Barney.
The people at NASA watch a show which is a spoof of this with charactes drawn to look like the originals and impressions of them and similar jokes.
The people at NASA watch an animated version of this show which lampoons it.
Remake of the scene where Homer eats chips in space.