The Greek Orthodox church where Andy and Sylvia are married is actually Saint Sophia, in Los Angeles, California, the same church where actress Sharon Lawrence later married her husband, Dr. Tom Apostle, in 2002.
When Andy is quizzing Greg about caring for his saltwater fish, he asks him to diagnose a "white spot" on a fish. He then corrects Greg's mispronunciation of oodinium. Actually, oodinium (a parasite) presents as gold-colored dust, and not as the white spot commonly seen in freshwater ich (ichthyophthirius multifiliis). Greg continues by saying that he would "put the treatment in the water." The typical treatment for oodinium is copper.