Situated in New York City, also before this series begins, Grady invites his Aunt Jessica to stay at his apartment during her stay, for meetings with her publisher. However, Sommelier (Steve Tschudy) and Workman (Tony Ballen) are busy exterminating Grady's apartment building, and the two must make accommodations elsewhere.
When Grady informs Jessica that they have reservations at the extravagant Montaigne Plaza Hotel, he explains that the visit comes free of charge, as courtesy of his old college fraternity buddy, Garrett Harper (John Callahan), whom Jessica remembers from occasional visits to Cabot Cove, has married hotel owner Cornelia Montaigne Harper (Janet Leigh), causing Jessica to reflect upon Cornelia and Garrett's age difference.
After checking into Montaigne Plaza Hotel, Jessica and Grady are reacquainted with Garrett, who introduces Jessica to Cornelia and her right-hand assistant, Mark Havlin (Robert Desiderio).
Garrett then informs a delighted Grady that their favorite former college cheerleader, Sandra Clemens (Jennifer Holmes), has also arrived from South Bend, Indiana, and may eagerly anticipate a dinner invitation from Grady. She has stayed in Indiana to work as a computer programmer, but visits NYC on occasion.
Nettie Harper (Charlotte Rae), the mother of Garrett, is also reacquainted with Grady at dinner, with Jessica, Garrett and Sandra around the table, to the dismay of Cornelia, who suspects that Grady is covering for a two-timing Garrett, by including Sandra at the gathering.
A knowing Nettie forecasts fireworks to explode later in the evening, yet, during the effects of a thunderstorm, Grady stumbles upon a body.
NYPD Inspector Donald Matheney (Monte Markham) prioritizes his night at the opera and afternoon at an art gallery reception to investigating a crime, but Hotel Detective Fritz Rice (Macon McCalman) continuously searches for clues, which seem to implicate Grady Fletcher, who is promptly arrested for murder.
As usual, when Grady is falsely arrested, Jessica steps in to demand justice, by proving her nephew's innocence. However, bribes are paid to plant evidence to support the theory that Grady has done it.
Mrs. Townsend (Juli Reding), Husband (Kenny Davis) and Wife (Judy Kerr) hotel customers, hotel Cashier (Mary Ingersoll), hotel Maid (Sheila Shaw) and Aquarium Lady (Lynn Holt) round out the cast of this episode with a "Doom With a View."