On the coffee machine in the team's bullpen, the inscription reads "Good Coffee - cheaper than Prozac."
At numerous times in this episode, Dr. House plays "Metroid: Zero Mission" on his Game Boy Advance.
About four minutes in, House says that if they don't get the patient's blood pressure under control, the patient will be "circling the drain." The original working title for this show was "Chasing Zebras, Circling the Drain."