16-year-old Keith Foster suddenly starts bleeding while joy-riding with his cheeky girlfriend Pam behind the wheel of his dad's Porsche. Mr. Foster fears ex-junkie Pam got his good boy on drugs. Keith tests clean yet shows a confusing set of symptoms, including blood clots, hemophilia, liver failure, vomiting and hallucinations. After various negative tests and Chase's success at preventing him going blind, only hyper-rare hepatitis E (possibly caught on foreign travels) or lupus (immunity turning against the patient himself) seem likely. House, grumpier than usual, remains increasingly distracted due to a wager with Cuddy: one month off clinic duty for one week off Vicodin (to prove he's no addict). Through his haze of pain, House comes upon a possible clue to Keith's life-threatening ailment- a death in the family no one felt worthy of mention. Written by
KGF Vissers/revised by statmanjeff
Did You Know?
The coffee machine in the diagnostic room next to House's office says "Good Coffee - Cheaper than Prozac!" See more
Opiate is a term used to describe the naturally occurring narcotics in opium, which are mainly codeine and morphine, whereas opioid is a term used for the semi-synthetic analgesics like hydrocodone (Vicodin, Lortab and Norco), oxycodone (Percocet and OxyContin) and Hydromorphone (Dilaudid), as well as the fully synthetic narcotic analgesics like methadone and fentanyl. When House exhibits the effects of opioid withdrawal, Dr. Cuddy states it is because House is addicted to the Vicodin; however, just because someone is experiencing withdrawal after stopping an opiate or opioid does not mean that they are addicted. It just means that their body, mainly the brain and nervous system, had become tolerant to the drug. Only some people using opiates and opioids become addicted to them (meaning they take the drug for the high). Everyone else taking opiates or opioids for more then a couple weeks just becomes tolerant to the drug because of its similarity to chemicals secreted in the brain, mainly endorphins and dopamine (our bodies' natural painkiller and "feel good hormone"). In fact, endorphins are very similar to morphine, both chemically and in its effects on the nervous system; so, since these drugs are a lot like those chemical neurotransmitters secreted in the brain, the brain stops making them. Any sudden halt to taking opiates or opioids throws the brain into a chemical imbalance, which is what withdrawals are. Once our brains are able to catch up and start producing normal levels of endorphins and dopamine, the withdrawal subsides. To sum it up, going into withdrawal after the cessation of opiates or opioids does not necessarily mean one is addicted to them. See more
Dr. Gregory House
Your fourth diagnostic criterion for lupus is psychosis. This is just a kid missing his cat.
Dr. Robert Chase
He was being attacked by an animal that wasn't in the room! That's psychosis.
Dr. Gregory House
There is a difference between psychosis and hallucination.
Dr. Eric Foreman
So if he was imagining a fake cat it would be lupus, but since it was a real cat it's not?
You Don't Have To Worry
Written by Wayne Jones
and Windy Wagner
Performed by Windy Wagner See more