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This was the first episode of Grey's Anatomy I ever saw, in December 2005 on Italian TV (it aired right before a Nip/Tuck rerun I wanted to tape), based on my brother's recommendation. In a way, I'm glad I started watching the show regularly from this point (I saw the previous six episodes much later on DVD), as this is the one where all the main characters are already perfectly defined and allowed to interact in an appealing mixture of comedy and drama.Most satisfyingly, almost everyone has something relevant to do in this episode: Meredith and Derek keep getting hell from Bailey because of their relationship (even Izzie freaks out on the subject), George suspects an anesthesiologist drinks on the job, Izzie gets to deal with a patient who literally won't let his girlfriend go (he swallowed her keys) and Cristina gets what appears to be a bout of the flu.The Self-Destruct Button is, for the most part, a very funny episode, one that allows even the usually bland protagonist some better moments (not too many, though) and gives the likes of Wilson and Dempsey a chance to expand on the comedic potential they have shown previously, while leaving room for a subplot whose development promises to be very good. Plus, a key-swallowing guy: don't see that very often, huh?
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