- The Crane family keeps a tense vigil while Niles has open-heart surgery, each remembering various experiences they've had in hospitals.
- Niles must have a bypass heart surgery. As the main characters wait for Niles, they experience flashbacks of their visits at the hospital including; 1. Niles is injured from an accident caused by Fraiser as kids and Fraiser bribes Niles not to tell by giving him an Archie comic. 2. Young Fraiser meets Baby Niles for the first time and isn't happy about it. 3. Roz freaking out when she sees red on Alice's face, which is revealed to be lipstick from herself. The nurse assisting her realizes that this is Roz's first time as a mother. This flashback is triggered when Roz and the nurse talk for a moment but have no memory of each other. 4. Marty is given the news that Hester is dying of cancer. 5. In a flash forward, Niles is holding his and Daphne's son, David (who is born in the Series Finale), and introduces him to his new baby sister, who is being held by their mother Daphne.
- Niles has been taken to hospital, and is about to undergo heart surgery. Daphne, Frasier, Martin and Roz have all come to see him, and each is coping differently: Martin jovially pretends there is no problem, and that Niles is just avoiding work; Frasier has researched the medical procedure thoroughly, and keeps offering to talk everyone through it; Daphne is just terrified, and Roz does her best to look after her. Frasier irritates the surgeon by asking questions about the operation, and by suggesting that he knows a better way of doing it, just because his source is a colleague from Harvard. Niles, on his way to the operating room, speculates over whether a hospital has memories. Then, at several points while the others wait for the operation to finish, little scenes from their past are played out around them in different parts of the hospital, including when Niles was born, when Roz brought baby Alice in for a check-up, and when Martin received bad news about his wife's health. Once Niles' surgery is over and a relieved Daphne is leaving the hospital, the hospital shows us a hopeful scene from the future in which she and Niles welcome a second child.
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