Jay Johnson is a Witt/Thomas/Harris alum playing Bob Campbell, as well as his ventriloquist dummy alter ego Chuck Campbell, on Soap from 1977 to 1981. Although not mentioned by name, Johnson reprises his character, as well as his ventriloquist bit, from Soap in this episode.
This episode was the second part of a 2 hour crossover event with The Golden Girls and Nurses, with various characters crossing over. The connecting thread being that a full moon on February 29th is causing strange behaviour in people.
The title makes reference to the novel 'The Strange Case of Dr Jekyll and Mr Hyde' by Robert Louis Stevenson.