As Dr. Mike and the other residents of Colorado Springs prepare for the Thanksgiving holiday and the opening of Preston's new hotel, they are unaware that a deadly storm is approaching that could threaten their lives. As storm clouds begin to gather, Dr. Mike is trying her limited culinary skills in an attempt to create a traditional Thanksgiving meal - while a somewhat dubious Sully and Brian watch her efforts. But the joy of the holiday is threatened by more than bad weather when she learns that Andrew is opening a rival medical clinic and, worse yet, neither Matthew nor Colleen may be able to get home for Thanksgiving. Meanwhile, Preston Lodge III is finding that it isn't easy impressing his visiting father, the very formidable Preston Lodge II, who is in town for the new hotel opening. As the full fury of the storm hits and Dr. Mike fights to save herself and her baby, the entire town learns the real meaning of Thanksgiving.