(at around 13 mins) Senator Corman says that his son is studying "landscape architecture at Georgetown". Georgetown University does not offer "landscape architecture" as a course of study. The closest school to Washington D.C. that does offer it would be the University of Maryland, College Park.
The goof item below may give away important plot points.
When Dr. Brennan and Angela are reconstructing the scene when the victim was deadly injured they say that the house manager name is "Hector Santiago" but later when Booth arrest him he call the suspect "Hector Alvarado".