In this pilot, Blossom lives with both of her parents. But in the following series, they are divorced and Blossom lives with her father. Also, in this pilot, Blossom's father is named Terry (played by Richard Masur) and works as an accountant. In the series, her father is named Nick (played by Ted Wass) and works as a musician.
When the producers were doing the casting for the part of Blossom's brother Tony, Mayim Bialik picked the actor to play her brother Tony (Michael Stoyanov) because she thought that Michael looked more like her than her real life brother.