Sherlock Holmes: When a doctor goes wrong, he is the first of criminals. He has nerve. He has knowledge. Palmer and Pritchard were among the heads of their profession; this man strikes even deeper.
Sherlock Holmes: Do not fall asleep. Your very life may depend on it.
[after Dr. Roylott storms out, Holmes picks up the poker he bent and laughs]
Sherlock Holmes: What a very amiable person. I am not quite so bulky, but...
Sherlock Holmes: [With a sudden effort, he straightens the poker out again] Fancy his having the insolence to confound me with the official police force. This incident gives zest to our investigation.
Sherlock Holmes: Mrs. Hudson, do you think you could bring this young lady a hot cup of coffee, for I observe you are shivering.
Helen Stoner: It is not cold which makes me shiver.
Sherlock Holmes: What, then?
Helen Stoner: It is fear, Mr. Holmes. It is terror!
Sherlock Holmes: Well, you must not fear. We shall set matters right; have no doubt.
Sherlock Holmes: You have come by train, I see, this morning.
Helen Stoner: You know me, then?
Sherlock Holmes: No, but I observe the second half of a return ticket in the palm of your left glove. You started early, but you had a drive in a dog-cart, along heavy roads, before you reached the station. There is no mystery, my dear lady: the left arm of your jacket is spattered with mud in no less than seven places, the marks are fresh. There is no vehicle save a dog-cart which throws up mud in that particular way, and then only when you sit on the left-hand side of the driver.
Helen Stoner: You are perfectly correct.
Julia Stoner: [falls to the ground, writhing in pain] Oh, my God, Helen! It was the band... the speckled band!
Dr. Grimesby Roylott: You scoundrel, sir. I've heard of you before! You are Holmes the meddler, Holmes the busybody, Holmes the Scotland Yard Jack-in-office!
Sherlock Holmes: [short burst of laughter] Your conversation really is most entertaining. If you would close the door, on your way out, as there is a decided draught.
Dr. Grimesby Roylott: [having just bent Holmes' fireplace poker in half] I am a dangerous man to fall foul of.
Sherlock Holmes: Ah, Watson, it's a wicked world. And when a clever man turns his brain to crime, it's the worst of all.
Sherlock Holmes: [while examining Miss Stoner's window, Holmes turns and sees Watson examining the ground] What are you doing, Watson?
Dr. John Watson: Well, I'm using your methods, Holmes; seeing whether the ground has been disturbed.
Sherlock Holmes: And what have you come up with?
Dr. John Watson: Your footprints, I believe,
Dr. John Watson: and mine and Miss Stoner's. And this.
[points to pawprint of a leopard]
Sherlock Holmes: Miss Stoner, it is very essential that you absolutely follow my advice in every respect. Your life may depend on it.
Helen Stoner: I assure you that I'm in your hands.
Dr. John Watson: You evidently saw more in those rooms than was visible to me, Holmes.
Sherlock Holmes: No. But I probably deduced a little more.
Sherlock Holmes: You will excuse me while I satisfy myself as to this floor.
Dr. Grimesby Roylott: Which one of you is Holmes?
Sherlock Holmes: My name, sir, but you have the advantage of me.
Thorne: [chasing a boy] Come here, lad.
Dr. Grimesby Roylott: What are you doing on my property?
Thorne: Come to claim back what's rightfully mine, sir. That thieving young rascal made off with some horseshoes and a bag of nails from my smithy.
Dr. Grimesby Roylott: Where is your proof?
Thorne: The proof is I'll find 'em there. Now, I don't want to be forced to call the police.
Dr. Grimesby Roylott: These people are guests of mine, but you are trespassing, Mister Thorne.
Thorne: I'm not frightened of you, Doctor.
Dr. Grimesby Roylott: Get off my land!
[Holmes and Watson cross the grounds of the Roylott estate at night, heading towards the house when Holmes stops]
Sherlock Holmes: Down!
[Holmes and Watson crouch in the tall grass as an animal crosses their path]
Dr. John Watson: My God, what's that?
Sherlock Holmes: It's the baboon. This is a nice household.
Sherlock Holmes: Let us meet again at one, under the clock at Waterloo Station. That is, if you've finished your breakfast by then. Oh, and your revolver. I would be obliged if you would slip it into your pocket; an Eley No. 2 is an excellent argument against gentlemen who can twist steel pokers into knots.
Sherlock Holmes: Last night when I attacked the snake and drove it back through the ventilator, I roused its snakish temper, causing it to turn upon the next person that it saw.
Dr Watson: Doctor Grimesby Roylott. So you, Holmes, were indirectly responsible for his death.
Sherlock Holmes: I cannot say that it is likely to weigh very heavily on my conscience.