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The US government asks Brisco to transport a female prisoner to Mexico to avert a war with Spain. However, some renegade members of the US government desire war and hire an assasin to join Brisco, his prisoner, and several other passengers on the stagecoach to Mexico. Everyone is a suspect as one-by-one the passengers begin to die. Bowler and Socrates try to catch up with Brisco to save his life and ensure that the prisoner arrives to Mexico City in time.