| Photos (see all 2 | slideshow) |
| Marlee Matlin | ... | Amanda | |
| Elaine Hendrix | ... | Jennifer | |
| Barry Newman | ... | Frank | |
| Armin Shimerman | ... | Old Man | |
| Robert Bailey Jr. | ... | Reggie | |
| John Ross Bowie | ... | Elliot | |
| Larry Brandenburg | ... | Bruno | |
| William Joseph Elk III | ... | Medicine Man | |
| Danielle Serra | ... | Bride | |
| James Langston Drake | ... | Groom | |
| Michele Mariana | ... | Tour Guide | |
| Robert Blanche | ... | Bob | |
| Pavel Mikoloski | ... | Priest | |
| Alex Rogers | ... | Guy No. 1 | |
| Tin Tran | ... | Guy No. 2 | |
| Leslie Taylor | ... | Bridesmaid | |
| Sherilyn Lawson | ... | Bridesmaid | |
| Mercedes Rose | ... | Bridesmaid | |
| Heather Robertson | ... | Bridesmaid | |
| Joelle Anthony | ... | Bridesmaid | |
| Dawnn Pavlonnis | ... | Bridesmaid | |
| Danny Bruno | ... | Caterer | |
| Josh Santos | ... | Best Man | |
| Kerensa Gimre | ... | Kid | |
| Patti Collins | ... | Mother of the Bride | |
| Tammy Mischke | ... | Chick | |
| Justin Canfield | ... | DJ | |
| Gordon Grobelny | ... | Guitar Player | |
| Brent Pendleton | ... | Conga Player | |
| Hannah Childs | ... | Marlee Stand In | |
| Jonathan Cammon | ... | Player | |
| Val Landrum | ... | Ticket Sales Girl | |
| Kyle Lunde | ... | Bartender | |
| David Albert | ... | Himself | |
| Amit Goswami | ... | Himself | |
| John Hagelin | ... | Himself | |
| Dean Radin Ph.D. | ... | Himself | |
| William Tiller | ... | Himself | |
| Fred Alan Wolf | ... | Himself | |
| Joseph Dispenza | ... | Himself | |
| Dr. Masaru Emoto | ... | Himself | |
| Stuart Hameroff | ... | Himself | |
| Daniel Monti | ... | Himself | |
| Andrew Newberg | ... | Himself (as Dr. Andrew Newberg) | |
| Jeffrey Satinover | ... | Himself | |
| Miceal Ledwith | ... | Himself | |
| J.Z. Knight | ... | Ramtha | |
| Lynne McTaggart | ... | Herself | |
| rest of cast listed alphabetically: | |||
| John Astin | ... | Dr. Quantum (voice) | |
| Dr. Candace Pert | ... | Herself | |
| Dean Radin | ... | Himself | |
Directed by | |||
| William Arntz | |||
| Betsy Chasse | |||
| Mark Vicente | |||
Produced by | |||
| William Arntz | .... | producer | |
| Betsy Chasse | .... | producer | |
| Mark Vicente | .... | producer | |
Original Music by | |||
| Christopher Franke | |||
Film Editing by | |||
| William Arntz | |||
| Jonathan P. Shaw | (original version) | ||
Casting by | |||
| Danny Stoltz | |||
Production Design by | |||
| Nava | |||
Art Direction by | |||
| Geoffry Mellon | |||
Makeup Department | |||
| E. Larry Day | .... | hair department head | |
| E. Larry Day | .... | makeup department head | |
Sound Department | |||
| Roy Braverman | .... | foley mixer | |
| Stanley Kastner | .... | sound re-recording mixer | |
| Assaf Lotan | .... | sound recordist | |
| Donald Lyles | .... | sound re-recording mixer | |
| Clancy T. Troutman | .... | supervising sound editor | |
| Scott Westley | .... | sound designer | |
Visual Effects by | |||
| David M. Blum | .... | visual effects supervisor | |
| Evan Jacobs | .... | visual effects supervisor | |
| Doug Juno | .... | animator | |
| Todd Juno | .... | animator | |
| Patrick Moore | .... | animator | |
| Gabriel Naylor | .... | digital compositor | |
| Tamiko Styre | .... | digital artist | |
| Tamiko Styre | .... | visual effects coordinator | |
Animation Department | |||
| Tom Elleman | .... | animation director | |
| Kyle Kenworthy | .... | animator | |
| Jayna Longenbaugh | .... | animator | |
| John Longenbaugh | .... | animator | |
Casting Department | |||
| Carol Stanzione | .... | adr voice casting | |
Editorial Department | |||
| Brian J. Cavanaugh | .... | first assistant editor | |
| George Chavez | .... | color timer | |
| Jason Henderson | .... | second assistant editor | |
Music Department | |||
| Edgar Rothermich | .... | music producer | |
| Edgar Rothermich | .... | music recordist | |
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| What the #$*! Do We (K)now!? | The Serious Business of Happiness | The Beaver Trilogy | Looking for Richard | Private Dicks: Men Exposed |
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| Full cast and crew | Company credits | External reviews |
| IMDb Documentary section | IMDb USA section | Add this title to MyMovies |
Unfortunately adding more isn't always better and in this case, this new version of the 2004 What the #$*! Do We (K)now!? is more of compilation pile-on of incompatible, convoluted patter that doesn't mesh well with the more simple storyline plus personal interview format of the original. Now instead, this new version has a third animated component as well as somewhat less professionally shot updated interviews that aren't seamlessly compatible with the original dramatic story or personal interviews that make the entire product more unmanageable, unwieldy and boring. For those who are really, really interested in this stuff, the updated version will provide more of the same along with even two modified concepts that push the envelope of reality even further.
There are spots of improvements including the wedding sequence and reflective, angry scene of Marlee Matlin, but much of the rest of the movie becomes unbalanced even with a somewhat extended drama, it becomes almost lost with the incessant interviews along side the addition of the child-like superhero cartoon figure as teacher. Even the new opening sequence is confusing and strange not mystic or appealing. Three out of Ten Stars. May be considered one of the worst remakes and movies of the year.