For Michael Chiklis's performance as the Thing, a new set of prosthetics were developed. These prosthetics were easier for Chiklis to wear, as they provided better ventilation and could be easily removed, in comparison to the previous film's prosthetics which required six hours to apply, were uncomfortable and could not be easily removed.
Originally Laurence Fishburne was keen to provide the voice for Galactus. He happily switched to the role of the Silver Surfer when it became clear that Galactus was not going to be represented in "human" form.
Supporting character "Captain Frankie Raye" shares her name with comic-book super-hero Nova's alter ego. In the comic-books Frankie Raye was a love interest of Johnny Storm and, as Nova, succeeded the Silver Surfer as herald of Galactus.
For this outing, some slight revisions were made to the make-up of The Thing, giving him a larger brow and broader shoulders. This brought the design more in line with the current comic book incarnation.
as a guest who is refused entry to the Fantastic wedding. This is in keeping with the 1960s "Fantastic Four" comic, where at Reed Richards and Susan Storm's wedding, two characters, obviously representing writer Lee and artist/plotter Jack Kirby, are also not allowed to attend the wedding.
The trivia items below may give away important plot points.
Although the film uses the premise that the Silver Surfer gets his powers from his board, this is clearly not the case in the comics. In the comics, the Surfer is able to fly on his own and use his full gamut of powers without the aid of his surfboard. He uses it, however, as it significantly decreases the energy required for flight.
According to Don Payne, the film was influenced by the Fantastic Four comic "The Galactus Trilogy" (Galactus and the Surfer approach Earth), "Fantastic 4" issues #57-60" (Dr Doom steals the Surfer's powers), and the "Ultimate Marvel" comic "Ultimate Extinction" (the name of Gah Lak Tus is used).
Tim Story once said that he would never have giant robots in any of his movies. In this film, Galactus, normally portrayed in the comics as something resembling a giant robot, is shown as a giant cloud. However, two hints to his physical appearance in the comic book are included in the film. Both the shadow on Saturn as he passes by it and the fiery mass within the cloud, resemble his signature helmet.