- Don Payne has said the film is based upon Fantastic Four issue #48, in which Galactus also makes an appearance, as well as issues 57-60 in which Doom steals the Surfer's power. Payne has also said the film takes inspiration from the Ultimate Marvel limited series Ultimate Extinction.
- Was given a PG rating by the MPAA, the first Marvel film since Howard the Duck (1986) to earn this rating.
- Stan Lee plays a rejected wedding guest in a cameo, in a tribute to his own fictional comic book incarnation. It has become a tradition for Lee to have cameo appearances in live-action adaptations of his comics; he appeared in the first _Fantastic Four (2004)_ film playing the Baxter Building's mailman, Willie Lumpkin.
- The cameo scene where Stan Lee is refused entry to the wedding is in keeping with the comic series. In the 1960s story of Reed Richards and Susan Storm's wedding, two characters, obviously representing writer Stan Lee and artist/plotter Jack Kirby, are also not allowed to attend the wedding.
- Release prints were delivered to theaters with the fake title 'Broom Field'.
- WILHELM SCREAM: When the Army and the Fantastic Four first have an up close encounter with the silver surfer.
- Although the film uses the premise that the Silver Surfer gets his powers from his board, this is clearly not the case in the comics. In the comics, the Surfer is able to fly on his own and use his full gamut of powers without the aid of his surfboard. He uses it, however, as it significantly decreases the energy required for flight.
- When The Torch falls into the sand in the Middle East and rolls over to his back, in close up shots you can see the "4" logo in the sand next to his head.
- Reed's speech to General Hager about being a "good little nerd" is taken nearly verbatim from Ultimate Extinction #2 (in there, he was speaking to Nick Fury).
- Supporting character "Captain Frankie Raye" shares her name with comic-book super-hero Nova's alter ego. In the comic-books Frankie Raye was a love interest of Johnny Storm and, as Nova, succeeded the Silver Surfer as herald of Galactus.
- The facility where the Silver Surfer is taken after being captured is named "Inyeptuk" - a nod to the FX show "Nip/Tuck" (2003), starring Julian McMahon, who plays Victor Von Doom.
- The wedding dress Jessica is wearing in the wedding scene is a custom made design by the German luxury fashion brand Escada.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: Tim Story once said that he would never have giant robots in any of his movies. In this film, Galactus, normally portrayed in the comics as something resembling a giant robot, is shown as a giant cloud.
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