Max sometimes wears a white glove or a black glove on his left hand, depending on the scene. In the comics, this is because Max is actually two agents who are twins; however in the film it's because of a nasty scar on his hand.
Director Sylvain White was attracted by the realistic nature of the comic to do the film: "What appealed to me about The Losers was that it wasn't the typical superhero-with-superpowers thing. It was based on real characters-realistic characters - and based in reality, like a lot of the European graphic novels that I had grown up reading."
When Jensen unlocks Max's hard drive, the code that comes up on screen is actually the source code of the web page for ordering a trial version of MathCore, a program for compiling mathematica functions.
The uniforms that the security company at the end of the film wears is the Navy Working Uniform made from digital camouflage. The color and pattern was designed specifically for the U.S. Navy. This is the first movie to be shown with this uniform worn by anyone.
Production designer Aaron Osborne and cinematographer Scott Kevan attempted to enhance the color scheme of the comics, where only two to three colors were used to convey the tone of each setting, so they charted the whole movie with certain color schemes for each location and different shades as time passed("Every chapter of the comic books is a new environment distinguished by different color palettes - so every time we are in a new city or country, the aesthetic of the film changes completely, so there is no homogeneous look. It's very eclectic.").
Both Chris Evans an Zoe Saldana went on to star in Marvel blockbusters. Evans in the Captain America and Avengers franchise and Saldana in Guardians of the Galaxy. In addition, Idris Elba played the role of Heimdall in the Thor series by Marvel.
Originally Tim Story was to direct, citing influences from the war drama Black Hawk Down (2001) and the television miniseries Band of Brothers (2001): "I was looking for a film that would have edge, but I wanted to keep the tongue-and-cheek, where the characters have a little fun with each other." He was later replaced with Sylvain White.
When Jensen enters through the warehouse roof at the Port of Los Angeles to let Clay and Roque in the door, he says "Disco" as he touches down on the ground to signify that he's arrived. Chris Evans previously played Det. Paul Diskant in the movie Street Kings and his nickname was Disco, although he didn't particularly like the nickname.
The trivia items below may give away important plot points.
When Roque enters the store through the ceiling after Jensen is shot, he drops down near a long display of dolls called "Girls Of America". They're the same dolls Jensen and Cougar were assembling in the Bolivian factory.