Wormwood, the name of the forest where blood is shed in the main characters' journey, is also the name of a destructive entity found in the Bible. This entity, described as a star, is called Wormwood (from a Greek word also translated as Bitterness) and appears to cause a plague-like (or poisoning) effect. From the Book of Revelation 8:10-11 we read "The third angel sounded his trumpet, and a great star, blazing like a torch, fell from the sky on a third of the rivers and on the springs of water--the name of the star is Wormwood. A third of the waters turned bitter, and many people died from the waters that had become bitter."
Test screenings reportedly did not impress Lionsgate executives and the studio decided to push back the originally planned March 2010 release date. The movie underwent reshoots in September 2010 in Shreveport, Louisiana.