Five seasons were planned. By the fifth season, Orel would have evolved from being naive and innocent to an emotionally mature person. According to creator Dino Stamatopoulos, the fifth season would have focused more on other townspeople and the title would have been changed to "Moralton".
Any chance of Dino extending the show beyond its unintended three seasons were destroyed when Adult Swim executives saw an early draft of the episode "Alone", which is the most dark and disturbing episode of the series, upon which the show was promptly cancelled and the season was cut in half from 20 episodes to 13. This is ironic considering the fact that the executives actually wanted the show to get darker after the two part Season Two finale, "Nature".
According to Scott Adsit, his staunchly Christian family were very offended by the content of the episode "God's Chef". His sister was so upset with him that they argued constantly. Adsit decided to quit the show. But a few days later, they decided to make up and Adsit rejoined the show.
The trivia item below may give away important plot points.
After the show was cancelled, many revelations about future episodes that were never made have since come to light. One example of this is a script that Dino leaked for an episode called "Rape" which built upon the backstory of the supporting character Miss Sculptham, wherein she and her elementary school class visit a prison so she can learn more about the man who raped her.