 | Arrested Development | ... | Themselves (segment "Tennessee") |
 | Ol' Dirty Bastard | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Eric B. | ... | Himself (segment "Microphone Fiend") (as Eric B. & Rakim) |
 | Biohazard | ... | Themselves (segment "Slam") |
 | Tawana Brawley | ... | Herself (segment "Fight the Power") |
 | Wu Tang Clan | ... | Themselves (segment "C.R.E.A.M.") |

| Ice Cube | ... | Himself (segments "Straight Outta Compton" and "It Was a Good Day") (as N.W.A.) |
 | Chuck D. | ... | Himself (segment "Fight the Power") (as Public Enemy) |
 | Inspectah Deck | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Leor Dimant | ... | Himself (segment "Jump Around") (as House of Pain) |
 | Dr. Dre | ... | Himself (segment "Straight Outta Compton") (as N.W.A.) |
 | Jermaine Dupri | ... | Himself (segment "Freaks Come Out at Night") |
 | Eazy-E | ... | Himself (segments "Straight Outta Compton" and "Real Compton City G's") (as N.W.A.) |
 | Dionne Farris | ... | Herself (segment "Tennessee") (as Arrested Development) |

| Sticky Fingaz | ... | Himself (segment "Slam") (as Onyx) |
 | Flavor Flav | ... | Himself (segment "Fight the Power") (as Public Enemy) |
 | The GZA | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Allen Hughes | ... | Himself (segment "Brenda's Got a Baby") |
 | Jalil Hutchins | ... | Himself (segment "Freaks Come Out at Night") (as Whodini) |
 | Ghostface Killah | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Masta Killa | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |

| Queen Latifah | ... | Herself (segment "U.N.I.T.Y.") |

| Method Man | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Money-B | ... | Himself (segment "Brenda's Got a Baby") |
 | Danny Boy O'Connor | ... | Himself (segment "Jump Around") (as House of Pain) |
 | Professor Griff | ... | Himself (segment "Fight the Power") (as Public Enemy) |
 | Public Enemy | ... | Themselves (segment "Fight the Power") |
 | Raekwon | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Rakim | ... | Himself (segment "Microphone Fiend") (as Eric B. & Rakim) |
 | M.C. Ren | ... | Himself (segment "Straight Outta Compton") (as N.W.A.) |
 | Vin Rock | ... | Little Dude (segment "U.N.I.T.Y.") |

| RZA | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Erik Schrody | ... | Himself (segment "Jump Around") (as House of Pain) |
 | Evan Seinfeld | ... | Himself (segment "Slam") |

| Tupac Shakur | ... | Himself (segment "Brenda's Got a Baby") (as 2Pac) |
 | Speech | ... | Himself (segment "Tennessee") (as Arrested Development) |
 | Fredro Starr | ... | Himself (segment "Slam") (as Onyx) |
 | U-God | ... | Himself (segment "C.R.E.A.M.") (as Wu-Tang Clan) |
 | Whodini | ... | Themselves (segment "Freaks Come Out at Night") |
 | Terminator X | ... | Himself (segment "Fight the Power") (as Public Enemy) |
 | DJ Yella | ... | Himself (segment "Straight Outta Compton") (as N.W.A.) |