Doc's voice is provided by Jim Byrnes, who played Joe Dawson on the TV series Highlander (1992). Doc is shown to be missing a leg from the knee down, a reference to Byrnes's real-life disability - Byrnes lost both his legs from the knee down when he was struck by a car in the 1970s, a disability which was written into the TV series, which established that Dawson lost his legs after stepping on a landmine in Vietnam. Byrnes also voices the bartender who serves MacLeod, another reference to the Dawson character, who owned a blues bar on the TV series.
The American version of the film is shorter than the Japanese version. Producer Galen Walker said in an interview that "about seven or eight" scenes were cut "just for timing, and just for pace of story", and admitted that director Yoshiaki Kawajiri was unhappy with the cuts. An opening exposition text, which is traditional for Highlander films, was also added to the American version.
The film was a joint American/Japanese production, with the American production company writing, producing, and providing music and voice acting, and the Japanese production company directing, storyboarding, and animating.
2nd animated Highlander installment that takes place in a post apocalyptic future, which an evil immortal rules the world. The other was the animated spin-off television series Highlander: The Animated Series (1994).
Alistair Abell auditioned for the role of Colin MacLeod over the phone. Abell auditioned with three other actors, and director Yoshiaki Kawajiri chose Abell when the American producers asked him to choose who he thought was best for the role.
A PS3 game of Highlander which was entitled Highlander: The Game had been developed, but was canceled. However, a trailer for the game was released. In the trailer, Colin MacLeod in a church in present day NYC has a flashback of challenging his immortal lover to a duel and embraces and kisses her and Connor fights an immortal in a forest, which he is stabbed and falls into a lake. He returns to fight his immortal lover had been beheaded by the immortal in the forest and back in the church in present NYC, MacLeod leaves and comes across the immortal whom fought him in the forest and prepares for armed combat.
Highlander: The Search for Vengeance succeeded which Highlander II: The Quickening (1991) failed. The film although it takes place in the future, kept the same mythology and elements and Colin MacLeod was not an extra terrestrial from another planet.