Sam and Dean Winchester were trained by their father to hunt the creatures of the supernatural. Now, their father has mysteriously disappeared while hunting the demon that killed their mother, 22 years ago.
A friend of John's calls Sam and Dean for help about a strange recording on the black box of a crashed plane. They soon realize that the demon which caused the crash is picking off the crash's only seven survivors.
Sam and Dean investigate an age-old urban legend known only as the Hook-Man, the spirit of a 2nd century pastor with a twisted sense of morals that is unknowingly being used as an innocent girl's attack dog.
Following visionary Sam's recent nightmare about the former Winchester home in Lawrence, Kansas, where the present dwellers, Jenny from Wichita and mother to two small kids, are suspiciously accident-prone, Dean reluctantly accepts to drive there. Dean and Sam reassure Jenny but follow up on the kids fear of a flaming creature in the closet. They consult Missouri Moseley, their father John's old medium friend, and together with the spirit of Mary Winchester, confront an evil poltergeist, but a second ghost intervenes and someone hides behind Missouri.
While investigating a haunting in an abandoned asylum and rescuing two teenagers who ventured in, Sam and Dean become trapped with the spirits of those who had died in a riot decades ago, one of which was a doctor who causes extreme rage in his victims.