Sam and Dean Winchester were trained by their father to hunt the creatures of the supernatural. Now, their father has mysteriously disappeared while hunting the demon that killed their mother, 22 years ago.
Sam and Dean are called in to investigate when a plane crashes under mysterious circumstances. Their investigation leads them to the conclusion that a demon is possessing people and causing them to crash the plane they are on. Things become more urgent when they discover that the demon is going after the 7 survivors of the crash, including the pilot and a stewardess.
All over the world, kids play the "Bloody Mary" game, daring each other to say her name three times in a mirror. But no one has even died from it. Until now. Sam and Dean must find a way to stop her before she claims another victim.
When one of Sam's old school friends is framed for the murder of his girlfriend, Sam and Dean investigate, discovering that a shapeshifter is responsible for that murder and possibly other similar murders.
Sam and Dean help a girl whose date became a victim of the "Hook Man," a famous urban legend that turns out to be real, in a small college town somewhere in Iowa. In order to save her and her father, the local minister, the brothers have to find the ghost's bones so they can destroy them. But Sam and Dean run into a problem when they discover that the bones are in an unmarked grave.
When Sam starts to have nightmares about their old home, he and Dean head back to Kansas. They soon discover that the new owners of their old house are being plagued by a malevolent entity, could it be the same thing that killed their mother many years earlier?
Sam and Dean investigate an abandoned sanitarium and discover that when the hospital was open, the patients held a revolt against the cruel and unusual experimental treatments carried out by the head doctor. Now the ghosts roam the halls, driving anyone who spends the night insane. While trying to rescue two lost teenagers, Sam is captured and turns against Dean.