Despite Dean's directive to forget about looking for a cure for the MOC, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a murder case where they run into Cole.
Sam and Dean investigate the murders of mediums in Lily Dale, the most "psychic" town in America. They discover that an angry spirit is killing off the psychics, but in a town full of people who claim to be summoning spirits, they have a little trouble identifying the medium controlling the ghost.
After a ballerina is found dead from dancing herself to death, Sam and Dean look into the case and discover the ballet slippers she wore were cursed. When Dean accidentally touches the shoes the power of the curse starts to take hold of him.
Sam and Dean discover that Frank's hard drive, containing everything on the leviathans, is now in Dick's company building. To retrieve it, they ask for help from one of the employees, a young computer hacker.