Sam and Dean try to help Castiel recover from Rowena's spell, while searching for Amara who has now grown into a young girl. Rowena tries to use her powers to protect herself from the Winchesters, while Crowley tries to use Amara for his personal gain.
Sam and Dean investigate a series of murders at a local B&B that also happens to be Lizzie Borden's old home. When a man tells them he saw a little girl around the B&B around the time of the murders, the brothers realize Amara may be responsible.
Castiel seeks out Metatron's help to stop the Darkness. However, Metatron is pretty happy with his new life as a freelance videographer for the local news and isn't inclined to help the Winchesters or Castiel.