Temperance Brennan is an anthropologist who writes about the character Kathy Reichs in her spare time. In real life, Kathy Reichs is an anthropologist who writes about the character Temperance Brennan.
Eric Millegan, who plays Dr. Zack Addy, a grad student younger than the other scientists, is actually one year older than T.J. Thyne (who plays Dr. Jack Hodgins), two years older than Emily Deschanel (who plays Dr. Temperance Brennan, his teacher), and four years older than Michaela Conlin (who plays Angela Montenegro).
Angela's father is played by ZZ Top member Billy Gibbons, and there have been several indications that the audience is supposed to understand that her father *is* Billy Gibbons (albeit a fictional version of Gibbons, since Angela is herself fictional). Although Angela's dad has never been given a name, before his first appearance Angela told her friends that her father is famous enough that they might recognize him immediately, and during Gibbons' appearances, there have been several references to the music of ZZ Top.
Almost every time Booth, played by David Boreanaz, is in front of the camera he has on him a watch, his FBI ID, a holstered sidearm, a Zippo lighter, Craps dice, a $100 poker chip, a floaty pen (they type where a girls clothes fall off when you turn it upside down), 3x5inch index cards, his light brown sunglasses, and he is wearing a St. Christopher medal. All of these items can be spotted being handled by Booth throughout the series.
Angela Montenegro's middle name is thought to be "Pearly Gates" which is the name of a guitar belonging to ZZ Top member Billy Gibbons, who plays Angela's father in some episodes. However, when she marries Hodgins (S5 E20) it is revealed that her legal name is not the name she has been using. She whispers it in to the ear of the judge marrying them but he does not repeat her name.
Bones works at the Jeffersonian Institute. There is no such place in Washington DC. However, the name is probably a play on the Smithsonian Institute. Shots of the outside of the actual Smithsonian are often used in the show also.
Originally, the weight they'd give the victim who was exactly like Brennan on "The Doctor in the Photo" would be 20lbs less than the weight that aired. Emily Deschanel had read the script and called the producers, asking them to put the weight closer to the reality.
There have been several references to Agent Seeley Booth being a "direct descendant" of John Wilkes Booth. In reality, is is highly unlikely that John Wilkes Booth had any direct descendants. As the assassin of Abraham Lincoln and the first-ever assassin of any U. S. president, Booth's life history has been exhaustively scrutinized by generations of historical scholars, and there is absolutely no evidence that he ever married or fathered any children, legitimate or illegitimate. Several of John Wilkes Booth's brothers and sisters did have children, but in genealogical terms, to be a *direct* descendant of J. W. Booth, Seeley Booth would have to be descended from a child of his, and not just a niece or nephew.
The Royal Diner, where Brennen and Booth (and occasionally the other characters) go to relax after work really exists in Washington - but the one in New Jersey (on Route 31 North), not the District of Columbia.
Up to season 3, Special Agent Seeley Booth has handled a Glock 17, a Magnum .357, a two-tone S&W Sigma (commonly misidentified as a Glock, both pistols look and function nearly identical, however Glock does not produce two-toned pistols), and a Tokyo Marui Hi-Capa 5.1 (Airsoft replica) with a tactical flashlight attachment, along with a Colt .22 back up weapon. While Doctor Temperance Brennan has handled a Colt .22 in 'The Pilot' where she shot a suspect as well as on several occasions to back Agent Booth, a very large Smith and Wesson M500 .50 Revolver in season 2, and Booth's Tokyo Marui Hi-Capa 5.1 Airsoft Replica when she shot Booth's stalker.