Two teenage girls go missing, one of which is soon found dead and freshly buried. The team soon suspects that the killings are related to the witness protection program.
Rossi determines that the case that haunts him has gone unsolved too long on its 20th anniversary, and the team horns in on his investigation despite his displeasure. Elsewhere, Reid and Hotchner interview a manipulative death-row convict.
When a spree killing begins in a small Texas town, Reid's identification with the killer may endanger the girl with him, and cause Reid to put his own life in jeopardy.
Hotchner and Rossi profile a woman who murdered her husband as a favor to the D.A. in Boston, although she may not like their findings. Back at the office, J.J.'s personalization of a stalker case baffles the rest of the team.
A suspected serial killer who's been in a coma since 2004 due to an accident when he was arrested wakes up 4 years later, with no memory of his past, not even his name. While he is tried in court, in which Hotch is testifying against him, the rest of the team investigates his past further.
People who apparently have nothing in common are being shot randomly in New York City and the team must determine whether it is the work of a single shooter or a team.
As the city is on high alert, the team begins to believe that they have made a mistake with the profile and that everything the terrorists have done so far may in fact just have been diversion for something even bigger.
On the anniversary of a serial killer's execution, a murder spree which appears to be connected to him begins and the team must try and understand his mind in order to stop it.
Reid and Prentiss, having gone undercover into an underground cult to investigate child abuse, get trapped inside the compound when a federal raid on it goes bad.
A greatly sadistic serial killer who disembowels women and forces them to clean it up before killing them proves difficult to catch thanks to his social charm and simple, yet clever, disguises.
A serial killer known as the Road Warrior is gunning down blonde women on roads in Orange County, California and the BAU suspect that the victims are surrogates and that it's only a matter of time before he kills the real one.