The BAU heads to St. Louis, Missouri where ten year old Andrew Taffert has gone missing. The reason it is a BAU case is that the Tafferts - father Malcolm Taffert and mother Lida Taffert - had been receiving prank calls...
Rossi determines that the case that haunts him has gone unsolved too long on its 20th anniversary, and the team horns in on his investigation despite his displeasure. Elsewhere, Reid and Hotchner interview a manipulative death-row convict.
Hotchner and Rossi profile a woman who murdered her husband as a favor to the D.A. in Boston, although she may not like their findings. Back at the office, J.J.'s personalization of a stalker case baffles the rest of the team.
A suspected serial killer who's been in a coma since 2004 due to an accident when he was arrested wakes up 4 years later, with no memory of his past, not even his name. While he is tried in court, in which Hotch is testifying against him, the rest of the team investigates his past further.
As the city is on high alert, the team begins to believe that they have made a mistake with the profile and that everything the terrorists have done so far may in fact just have been diversion for something even bigger.
A serial killer known as the Road Warrior is gunning down blonde women on roads in Orange County, California and the BAU suspect that the victims are surrogates and that it's only a matter of time before he kills the real one.